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Anti-CD38 antibodies mediate anti-myeloma activity through multiple mechanisms of action both in patients with RRMM and with newly diagnosed MM, although immunomodulatory effects may be greater in earlier disease settings in which the immune system has not been affected by prior treatments. Sanofi wins US approval for multiple myeloma drug in newly diagnosed patients Sanofi plans to advance blood cancer drugs known as anti-CD38 Sarclisa is an anti-CD38 therapy in combination with standard-of-care VRd to significantly reduce disease progression or death (by 40%) compared micrainin Anti-CD38 Antibody Drug Conjugate (STI-6129) in Patients With Relapsed or Refractory Multiple Myeloma. First Posted : Ap. Click by FCA Moraes 2024In conclusion, the incorporation of an anti-CD38 monoclonal antibody demonstrated a promising prospect for reshaping the established MM treatment paradigms. by A Gozzetti 2024 Cited by 38These drugs are: i) the immunomodulatory (IMIDs) thalidomide, lenalidomide, and pomalidomide; ii) the proteasome inhibitors (PIs) Bortezomib

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