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Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization. [7] [8] It is taken by mouth. [7] Duloxetine is a serotonin norepinephrine reuptake inhibitor (SNRI). [9] The recommended DRIZALMA SPRINKLE dosage is 60 mg once daily in adults with chronic musculoskeletal pain. Begin treatment at 30 mg once daily for one week, to lomedia 24 fe A technician checks out some Cymbalta capsules at a Lilly factory in Indianapolis. Darron Cummings/AP hide caption. toggle caption. Darron This draft guidance, when finalized, will represent the current thinking of the Food and Drug. Administration (FDA, or the Agency) on this topic. It is used to treat depression. It is used to treat anxiety. It is used to help painful nerve diseases and diabetic nerve problems.